Synthesis and Characterization of Novel N-Substituted-3-chloro-2-Azetidinones as Potential Anticonvulsant Agents.

Various substituted 4(m-hydroxy-p-methoxy phenyl)-1[(6'-fluoro-7'-substituted (1,3)-benzothiazol-2'-yl) amido-2- phenyl] 3-chloro azetidin–2–one containing different functional groups have been synthesized. The lead compounds were characterized by melting point, TLC, calculated elemental analysis, UV, IR, 1HNMR and Mass spectralstudies. The compounds were tested for Anticonvulsant studies by PTZ induced method and showed significant activity at low and high concentration compared to standard; still further studies are requested.