Mucoadhesive: As Oral Controlled Gastroretentive Drug Delivery System

Mucoadhesion is a field of current interest in the design of drug delivery systems. Mucoadhesive drugdelivery system prolong the residence time of the dosage form at the site of application or absorptionand facilitate an intimate contact of the dosage form with the underline absorption surface and thuscontribute to improved and / or better therapeutic performance of the drug. In recent years many suchmucoadhesive drug delivery systems have been developed for oral, buccal, nasal, rectal and vaginalroutes for both systemic and local effects. In this paper main prominence on gastrointestinal dosageforms along with concepts, mechanism of mucoadhesion, factors affecting mucoadhesion, permeationenhancers and evaluation methods and also some review regarding research work already been carried.An overview of the last decade’s discoveries on mucoadhesion and applications of mucoadhesive asdrug carriers is given. Mucoadhesive drug delivery systems with its various advantages have a lot ofpotential in formulating dosage forms for various chronic diseases.