Copper Complex of Diphenylamine Mercapto Carboxylic Acid And Its Anti-Inflammatory Activity

Diphenyl amine-2-mercapto-2'-carboxylic acid and its Cu (II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. In acute anti-inflammatory test Cu (II) complex was found to be more potent than Ibuprofen in normal and adrenalectomized rats but less effective in sub acute and chronic anti-inflammatory tests. It inhibited PGE2 like substances (25%) and Castor oil induced diarrhea (30%), but did not protect the mice against arachidonic acid induced mortality. However, it had very low degree of gastric irritation and without analgesic effect. Metal complexes had very low degree of gastric irritation so it can be safely used for the treatment of inflammation.