A Novel Thermo-Sensitive Sol-Gel Reversible Buccal Adhesive Property of Fluconazole in Situ Gel For Oral Thrush

The aim of this study was the formulation and examination of a novel thermo-responsive and bioadhesive in situ gelling drug delivery system, which can be used in the treatment of oral thrush. A bioadhesive polymer was used as a thermo responsive material, because poloxmer 188 and carbopol 934 has thermal gelation properties at certain temperature. The thermal gelation temperature 15% w/w poloxmer 188 and carbopol 934 1% w/w solutions is above body temperature, but by using different ratio of poloxmer and carbopol combination of system, it can be shifted near to body temperature. The optimized formulations were evaluated for gelling capacity, viscosity, gel strength, bioadhesive force, drug release, FTIR and DSC.