Effect of Ketoprofen Co-administration on Pharmacokinetic of Cefepime in Cow Calves

The pharmacokinetic of cefepime (5 mg/kg) was studied following intramuscular administration of cefepime alone and co-administered with ketoprofen (3 mg/kg) in cow calves. The concentration of cefepime in serum was detected by using High Performance Liquid Chromatography. Following single dose intravenous administration of cefepime, elimination half life (3.90±0.08 h), area under curve (48.68±2.53 μg.h/mL), body clearance (1.74±0.09 L/h/kg) and volume of distribution (0.52±0.03 L/kg) were determined. Following single dose intramuscular administration of cefepime alone, peak serum concentration (8.93±0.32 μg/mL) was obtained at 45 h. The absorption half life (t1/2Kα), volume of distribution (Vdarea), total body clearance (ClB) and elimination half life (t1/2β) of cefepime were 0.17±0.01 h, 0.79±0.05 L/kg, 1.76±0.10 L/h/kg and 5.15±0.09 h, respectively. No significant changes were reported in pharmacokinetic parameters following co-administration of cefepime with ketoprofen. Integration of pharmacokinetic data generated from the present study and minimum inhibitory concentration suggest that the cefepime can be administered intramuscularly (5 mg/kg) with ketoprofen at 12 h interval to combat susceptible bacterial infections in cow calves.