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The Effect of Preemptive Intraveneous Dexketoprofen Trometamol on Analgesia Quality CreatedDOI: 10.4328 Keywords: Dexketoprofen Trometamol , Abdominal Hystorectomy , Fentanyl Abstract: Aim: We investigated the fentanyl dose used in patient-controlled analgesia (PCA) of preemptive intravenous (IV) dexketoprofen trometamol (DKP) after abdominal hysterectomy. Material and Method: Following approval by the local ethics committee, 40 patients scheduled for ASA I-II abdominal hysterectomy were randomly divided into two groups. The anesthetic techniques were standardized. Group F (n=20): Placebo administered 30 minutes prior to operation and after 8 hours; Group D (n=20): 50mg IV dexketoprofen trometamol administered 30 minutes prior to operation and after 8 hours. When VAS>3, 1.5 %u03BCg/kg fentanyl was administered to both groups in the recovery room. At intervals and afterwards, analgesia was provided through PCA (bolus dose: 25 %u03BCg fentanyl; lock out period: 10 min.; 4-hr limit: 400 %u03BCg). VAS score, sedation score, fentanyl consumption, postoperative nausea and vomiting (PONV), and side-effects were recorded. Results: Demographic data and duration of surgery in the two groups were similar. Respiratory depression was not seen in either group. There was no significant difference based on the VAS score (p= 0.07). Nausea and vomiting were significantly higher in the Group F compared to Group D (p=0.03). Compared to Group F, PONV were less in Group D, at 12hr and 24hr postoperatively (p=0.03). Fentanyl consumption at 12 and 24 hours was lower in Group D than Group F (p=0.001). Discussion: In cases where 50 mg of intravenous dexketoprofen trometamol was administered, we observed that the fentanyl consumption decreased by 40%, analgesia quality increased and the incidence of sideeffects decreased.
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