Comparison of 3,000 and 5,000 IU aXa/day certoparin in the prevention of deep-vein thrombosis after total hip replacement

Mean age was 71？±？10？years with a higher prevalence of previous DVT (8vs.4%) and pulmonary embolism (PE) (4vs.1%) in the high dose group. Mean duration of surgery was 82？±？32 and 85？±？36 min. DVT was detected in 28 (11.1%) of the low dose and 35 (14.1%) of the high dose group (p？=？n.s.). Combined distal-proximal DVT was observed in 5 (2%) and 4 (1.6%) patients respectively. No difference in bleeding events was found.This trial confirms prior data showing that the conventional dosage of 3,000？IU aXa is effective and safe for the prevention of venous thromboembolic events after hip replacement surgery.