The Effect of Hydroalcoholic Extracts of Prangos Ferulacea on Blood Factors of Kidney and Liver Functions in Diabetic Male Wistar Rats

Background and Objective: Diabetes mellitus is a chronic disease recognized by a reduction in insulin secretion due to the malfunction of β cells in the pancreas or an increase in the cell's resistance to insulin. Prangos Ferulacea has been known as an analgesic and anti-inflammatory herb in the general population. The aim of the present study was to evaluate the effect of the hydroalcoholic extracts of Prangos Ferulacea on the blood factors of kidney and liver functions in diabetes induced by streptozotocin in Wistar rats. Materials and Methods: In this experimental study, six groups of animals were selected. Three groups out of six were administered with intra peritoneal injection of streptozotocin to induce diabetes. Group I was fed a normal diet. Group II and III of the animals received 300 and 500 mg/kg/day Prangos Ferulacea extract. Group IV received distilled water (diabetic control), and the animals of groups V and VI were treated with Prangos Ferulacea extract 300 and 500 mg/kg body weight, respectively, for three weeks. Blood glucose, ALT, AST, ALP, creatinine, albumin, urea and BUN were measured in all the animals. The collected data were analyzed using SPSS software via the one-way ANOVA. Results: Treatment with the Prangos Ferulacea extract resulted in a significant decrease in blood glucose, ALT, AST and creatinine but no significant decrease in ALP, albumin, urea, and BUN levels. Conclusion: The results of this study showed that hydroalcoholic extracts of Prangos Ferulacea had antidiabetic effects and consequently might alleviate the liver and kidney damage caused by streptozotocin-induced diabetes mellitus.