The Role of Bee Venom in Ameliorating the Physiological Changes of Carbimazole Induced Hypothyroidism in Pregnant Rats

The present work was planned to investigate the role played by Bee Venom in improving the changes induced by carbimazole in pregnant albino rats and their embryos. A total number of 60 mature virgin female and 30 male Wistar wistar albino rats (for fertilization).Pregnancy was ascertained by vaginal smears.The experimental animals were divided into 2 main groups: - The experimental control group (normal group): In this group the pregnant rats were injected intraperitonealy by distilled water (the solvent of both carbimazole and bee venom) by dose 1ml/200g.body weight, from day 1 to day 18 of gestation.Π-The group of treated animals: this group was divided into 3 subgroups:1-The carbimazole group: this group was divided into2 subgroups the pregnant rats were orally injected at a dose 2 and 3mg /200g.body weight, daily from day 1 to day 18 of gestation.2-The Bee Venom group: The pregnant rats were intraperitonealy injected with a dose 0.6 mg/200g. body weight at days 2,3,4,7,8,9,10,11,12,15 and 16 of gestation.3-The treatment group: The pregnant rats were intraperitonealy injected with Bee Venom at a dose 0.6 mg/200g. body weight 1 hour after the intraperitonealy injection by the 2 doses of carbimazole (2 and 3mg /200g. body weight).The days of injection for both treatments (Bee Venom and carbimazole ) were as mentioned before . Carbimazole injection at the 2 doses revealed highly significant and very highly significant decrease of total serum proteins, serum albumin, serum T3and T4, however carbimazole injection induced very highly increase in serum globulin, serum AST and ALT. Bee Venom treatment showed improvement in all the above mentioned parameters.