MICROSCOPIA ELECTRONICA DE BARRIDO DE LA VELLOSIDAD PLACENTARIA CORRESPONDIENTE A FETO CON MúLTIPLES MALFORMACIONES CONGéNITAS

To describe the three dimensional structure of the placental villi with technics of scanning electron microscopy in a case of spontaneous abortion of 16 weeks gestation with multiple inherited malformations is the proposal of this work. Samples were taken of four marginal regions of the placenta and one of central region which were examined with conventional procedures of scanning electron microscopy previously being observed with light microscopy. Villi of another case of induced abortion at same gestational week were taken as control. Five specimens of each region were selected in delivery room and fixed in 2 percent of glutaraldehyde for their processing. The results showed immature intermediate villi with deposits of fibrinoid and scarce syncytial sprouts. The placental villi showed trophoblastic surface absent of microvilli and with a dense stroma or fibrotic. The surface no showed abundant syncytial sprouts. Villus scalloping with trophoblastic invaginations, were noted without alterations in branching of placental villi. It was found absence of placental hyperplasia or of stromal cisterns. The observations in the studied placenta exhibited a morphological pattern according to week 16 which no permit to predict about abnormal karyotypic. These no karyotyped samples observed sugest that mutations linked to X chromosome during blastogenesis could be cause of the multiple inherited fetal malformations.