Effects of oxidative stress on generation of age in senile myocardial infarction patients

Type 2 diabetes mellitus have a two- to four fold increased risk of myocardial infarction in senile patients. Oxidative stress has been reported to contribute to aging and myocardial infarction in type 2 diabetic patients. This study aims to determine the effects of oxidative stress on generation of AGE in senile myocardial infraction patients. Human serum samples of normal senile subjects (n=31), senile diabetic patients without myocardial infarction (n=33), senile diabetic patients with myocardial infarction (n=32), senile non-diabetic with myocardial infarction (n=30) and normal young subjects (n=31) were investigated. The patients were selected on clinical grounds from National Institute of Cardiova-scular Disease, Karachi and Jinnah Post-graduate Medical Centre, Karachi, Pakistan. Positive significant correlation was observed between s-AGEs and malondialdehyde in senile diabetic and non-diabetic patients with myocardial infarction. Negative significant correlation was observed between s-AGEs and vitamin-E in senile diabetic and non-diabetic patients with myocardial infarction. However, the malondialdehyde and serum AGEs were found to be significantly (P<0.001) increased in senile diabetic and non-diabetic patients with and without myocardial infarction as compared with senile control subjects. In contrast to all four senile groups, the serum AGEs was significantly (P<0.001) lower in young control subjects. Serum vitamin-E was found to be significantly (P<0.001) decreased in elderly diabetic patients with and without myocardial infarction as compared with senile control subjects. Fasting blood glucose, HbA1C and serum fructosamine levels were significantly (P<0.001) increased in senile diabetic patients with and without myocardial infarction as compared with non-diabetic senile patients with myocardial infarction and senile control subjects. This study revealed the effects of oxidative stress on generation of AGE in senile myocardial infraction patients. AGE as a result of oxidative stress might have a role in the myocardial infarction, which in diabetic patients occurs vigorously as compared with non-diabetic patients with myocardial infarction.