SYNERGISTIC ANTIBACTERIAL EFFECT OF METHANOLIC EXTRACT OF CERTAIN INDIAN MEDICINAL PLANTS

Aerial parts of Eclipta alba (L.), Centella asiatica (L.) and Phyllanthus amarus (L.) are used in treating various ailments skin, antinociceptive, stomach pain, anti-inflammatory, antiviral, rejuvenator, antimytotoxic, antihepatotoxic, antihyperglycemic, antioxidant and cancer. In this study, three plants are used individually to check their antimicrobial activity against Salmonella Typhi, Escherichia coli and Bacillus subtilis. P. amarus has exhibited maximum inhibition activity against E.coli (30±0.5 mm) followed by B. subtilis (28± 0.32 mm) and S. Typhi (24±0.16 mm). For the first time, we report the synergistic potential of these plants in the ratio of (1:1:1) against the test pathogens, which showed excellent antibacterial activity when compared with individual plant extract