Computer augmented modeling studies of Cu2+, Ni2+ and Co2+ complexes of ethambutol

The protonation and complexation equilibria of Ethambutol dihydrochloride have been studied pH-metrically in aqueous medium at an ionic strength of 0.1 mol dm-3 and 303K temperature. Its protonation constants as well as the binary stability constants of Cu2+, Ni2+ and Co2+complexes were evaluated and the best-fit models were chosenbased on the statistical parameters using MINIQUAD75 computer program. The species distribution diagrams of the binary metal complexes are reported.