全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Can the Presence of C-Kit-Positive Hepatic Progenitor Cells in Chronic Hepatitis C Have a Role in the Follow-Up of the Disease?

Keywords: CD117 antigen , hepatitis c virus

Full-Text   Cite this paper   Add to My Lib

Abstract:

Objective: The aim of this study was to compare the clinical and pathological properties of cases of hepatitis C virus (HCV) infection with respect to the presence or absence of hepatic progenitor cells positive for the proto-oncogene c-Kit (CD117) in hepatic tissue.Material and Methods: The study was performed on hepatic biopsy specimens from 61 cases with HCV infection. Stained hepatic biopsy slides were examined. Immunohistochemical staining was performed using an anti-c-Kit antibody. The cases were divided into four groups (minimal, mild, moderate and severe according to their total hepatic activity index and into two groups (none/mild, moderate/severe) according to fibrosis grade.Results: c-Kit-positive oval cells were detected in 30 cases (49.1%). There was no statistically significant difference in c-Kit positivity status with respect to the ALT, AST or HCV RNA results. c-Kit positivity increased with increasing hepatitis grade (p<0.001). In cases with moderate/severe fibrosis, c-Kit positivity was found to be higher than in cases with no fibrosis or low-grade fibrosis (p<0.02). Conclusion: It was found that HCV patients with more inflammation and fibrosis were more likely to present c-Kit-positive hepatic progenitor cells. c-Kit expression in hepatic progenitor cells could possibly be used in the follow-up of patients with HCV. Larger patient cohorts are needed to confirm these results.

Full-Text

comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413