Improvement of Bioavailability of Poorly Soluble Drugs through Self Emulsifying Drug Delivery System

Self emulsifying drug delivery system (SEDDS) has received particular attention as a means of improvement of oral bioavailability poorly soluble and absorbed drugs. SEDDS are the mixture of oils,surfactants, and co-surfactants. This becomes emulsify when come in contact with aqueous solution of GIT under the condition of gentle stirring and digestive motility. SEDDS includes various dosage forms like capsule, tablets, beads, microspheres, nanospheres, etc. thus SEDDS could efficiently improve oral absorption of the sparingly soluble drugs by self-emulsification. For the improvement of bio-availability of drugs with such properties presents one of the greatest challenges in drug formulations. Various technological strategies are reported in the literature including cyclodextrines complex formation, solid dispersions, or micronization, and different technologies of drug delivery systems. Including these approaches self-emulsifying drug delivery system (SEDDS) has gained more attention for enhancement of oral bio-availability with reduction in dose. SEDDS are isotropic mixtures of oil, surfactants, solvents and cosolvents/surfactants. For lipophilic drugs, which have dissolution rate-limited absorption, SEDDS may be a promising strategy to improve the rate and extent of oral absorption.