Soft tissue augmentation by autologous cultured fibroblasts transplantation for treatment of the wrinkles and scars; a case series of 20 patients.

There are many filler agents for augmentation of static wrinkles and atrophic scar with synthetic, biosynthetic, cadaver, animal and human sources. The current study presents 20 patients with facial wrinkles and lines whom were treated by transplantation of autologous cultured fibroblasts. The fibroblast nature of cells was confirmed by immune-staining and flow cytometry. The mean of improvement for this procedure at the 6 month follow up was 41%. Overall, the results of the current and other studies show that autologous fibroblast transplantation can be an effective procedure for correction of wrinkles and atrophic scars. Although this procedure seems to have low side effects, however, further studies with longer follow up seem to be mandatory to further confirm the permanence of this procedure