Oral Bioavailability of Simvastatin Novel Formulation in Albino Rats

The aim of this study was to compare the single dose oral bioavailability of two formulations of Simvastatin in albino rats. Plasma was analyzed for simvastatin using a sensitive, reproducible, accurate and validated LC-MS/MS method. Pharmacokinetic parameters including AUC0-t, AUC0-∞, Cmax, Tmax, and t1/2 were determined from plasma concentration for both formulations. Self-emulsifying Formulation of simvastatin showed a significant improvement in bioavailability (1.5 fold) as compared with the conventional tablets.