Comparative Dissolution Study of Glipizide by Solid Dispersion Technique

The aim of this study was to increase the solubility and dissolution of Glipizide in water by solid dispersion. The solid dispersion of glipizide was prepared using water soluble carriers such as polyethylene glycol (PEG) and mannitol by fusion method and PVP K 30 by solvent evaporation method in an attempt to increase the solubilityand dissolution rate of Glipizide- a practically insoluble drug in water. IR spectroscopy and in-vitro dissolution studies were used to characterize the solid dispersion. FTIR studies show no chemical interaction between Glipizide and PEG 6000, mannitol and PVP K 30. The solid dispersion prepared in this study was found to have higher dissolution rate and solubility compared to plain drug and physical mixture of drug and carriers. It was found that the optimum weight ratio 1.5 for PEG-6000 shows higher solubility and dissolution rate. Finally it was concluded that PEG-6000 shows greater dissolution enhancing capacity than mannitol and PVP K 30.