Formulation and Evaluation of Hydrogel Based Oral Controlled Drug Delivery System for Antihypertensive Drug

The objective of the study was to develop controlled release matrix tablets of Losartan potassium by simplex lattice design and evaluating the relationship and influence of different content levels of HPMC, Eudragit RSPO, Eudragit RLPO and ethylcellulose, in order to achieve a zero-order release of Losartan potassium. Tablets were prepared by wet granulation process. In-vitro drug release study revealed that HPMC causes initial burst release of drug hence combining HPMC with Eudragit sustained the action for 8hrs (95.92±0.57% release). Fitting the in-vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism for drug release. In conclusion, results suggest that drug release kinetics from theseformulations corresponded best to zero-order kinetics. Compared to conventional tablets, release of model drug from these HPMC matrix tablets was prolonged, leading to achieve an effective therapy with low dosage of the drug, to reduce the frequency of medication.