Nephroprotective Evaluation of Ethanolic Extract of the Seeds of Papaya and Pumpkin Fruit in Cisplatin-induced Nephrotoxicity

The present study is focused on the Nephroprotective evaluation of ethanolic extract of the papaya seed, PaSE ( Biological name- Carica papaya, family – Caricaceae) and pumpkin seed, PuSE (Biological name - Curcubita pepo, family – Curcurbitaceae). Cisplatin (10mg/kg, i.p.)used for the nephrotoxicity, which is the dose limiting side effect of the Cisplatin (Cis-diamine dichloro platinum-II). The ethanolic extract of PaSE & PuSE exhibited protection against cisplatin-induced nephrotoxicity, which were proved by the gross behavioural studies,histopathological, renal function and biochemical studies. Antioxidant studies like nitric oxide scavenging activity, lipid peroxidation in kidney also supporting the nephroprotective activity of these seeds. This nephroprotective study also compared with chloroform extract of the dried Zinger roots, ZE (Zingiber officinale Rosc, Family- Zingiberaceae) and methimazole (MZL) which is already evaluated. Histopathological investigation of the kidney like glomerularcongestion, blood vessel congestion, intestinal edema, inflammatory cells, necrosis, tubular casts were also observed for control, test and reference groups.