Synthesis of some 1H-indole-2, 3-dione Derivatives as Antibacterial, Analgesic and Antiinflammatory Agents

The starting compound 1H-indole-2,3-dione on reaction with different substituted anilines formed the Schiff bases. The corresponding N-Mannich bases have been prepared by the reaction of the Schiff bases with diphenylamine in the presence of formaldehyde. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The synthesized Mannich bases were screened for their antibacterial, analgesic and anti-inflammatory activities by the standard methods. Among the tested compounds, the compound containing chloro group showed the most favorable activity.