Análise da evolu o de culturas neurais

This paper analyses the electrical activity recorded in an experiment involving the maturation of dissociated embryonic hippocampal cultures, using Multielectrode Array (MEA) devices, starting from the moment of the culture's placement in the device until its death, a period of 0 to 88 days in vitro (DIV). Classical "spike" analysis is applied to three different cultures, showing the progression of spikes and "bursts". Particular attention is devoted to the last step associated with cellular death, as an unexpected rise in electrical activity amplitude is observed.