AVALIA O IN VITRO DO FATOR DE PROTE O SOLAR A PARTIR DE FOTOPROTETORES MANIPULADOS CONTENDO AGENTES ATIVOS ANTIENVELHECIMENTO

Critical issues have taken place involving potential interactions between sunscreen components and the components of antiaging active (AA) agents. Critical issues have taken place involving potential interactions between sunscreen components and the components of antiaging active (AA) agents. The aim was to evaluate compounded sunscreens containing different AA agents with or without fragrance, which were submitted to macroscopic analysis, centrifugation, pH determination and in vitro sun protection factor (SPF). All preparations presented physical stability. However, formulations containing Deanol exhibited pH significantly lower than the others independent to the fragrance, indicating that the stability of these formulations may be lower. As regards in vitro SPF variation no significantly difference was found after adding to AA agent into compounded sunscreens. However, sunscreens containing Enteline presented SPF significantly higher in formulations with no fragrance. In conclusion, the preparations studied showed physical stability and the pH range of stability presented in accordance with the need for compounded sunscreens containing Longevicell , Enteline or Iris Iso as AA agents. Nevertheless, formulations containing Deanol should be adjusted to pH range (6.0 – 7.0), regardless of the fragrance. Furthermore, the fragrance used in compounded sunscreens containing Enteline assessed in this work can significantly decrease the SPF in the preparation and should be avoided in order to ensure the safety and efficacy of sunscreens associated with AA agents.