Evaluation of Anti-Inflammatory, Analgesic and Antipyretic Effect of Mangifera indica Leaf Extract on Fever-Induced Albino Rats (Wistar)

This study was designed to evaluate the anti-inflammatory, analgesic and antipyretic effects of Mangifera indica leaf extract. The effects of the leaf extract on anti-inflammatory response using fresh egg albumin-induced paw edema model, analgesic activity of the extract using hot plate model to induce pain and anti-pyretic activity using Baker’s yeast fever induction model were examined. The research work was carried out using rats weighing between 150-210 g. These rats were divided into five (5) groups of 5 animals each; Group 1 served as the control group. Other groups were administered at a dosage of 100, 200 and 400 mg/kg, respectively. The extract (at the dose various dosages and in a time dependent manner) significantly (p<0.05) decreased the paw oedema induced by fresh egg-albumin in rats. This result supports the use of Mangifera indica leaf extract for the management of inflammatory disorders. Phytochemical analysis of the extract composition demonstrated the presence of alkaloids, anthraquinones, reducing sugars, flavonoids, glycosides, saponins, cardiac glycosides, steroids and tannins.