Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe

Aqueous extracts of Zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 g/L. The antidiabetic effects were found to be dose-dependent. Antidiabetic potential of Zingiber officinale was mainly through inhibition of the glucose diffusion and to a limited extent by reducing the glycation. However, further studies are needed to determine in vitro effects of therapeutic potential by restraining postprandial glucose absorptions and plasma protein glycations in diabetic subjects. Extratos aquosos de rizomas Zingiber officinale foram estudados para avaliar os seus efeitos antidiabéticos em glica o de proteínas e sobre a difus o de glicose in vitro, no presente estudo. Extratos aquosos de Zingiber officinale foram examinados nas concentra es de 5, 10, 20 e 40 g extrato de planta/L. Os efeitos antidiabéticos observados eram dependentes da dose. O potencial antidiabético de Zingiber officinale se verificou, principalmente, através da inibi o da difus o de glicose e, em menor extens o, através da redu o da glica o. Estudos adicionais s o necessários para elucidar se efeitos in vitro representam potencial terapêutico, restringindo a absor o de glicose pós-prandial e a glica o de proteínas plasmáticas em indivíduos diabéticos.