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D-α-tocopherol reduces renal damage in hypertensive ratsDOI: 10.1590/s1984-82502012000200013 Keywords: Hipertens o arterial , Les o renal , Aumento glomerular , Hipertrofia vascular , D-α-tocoferol , Hypertension , Renal injury , Glomerular enlargement , Vascular hypertrophy , D-α-tocopherol Abstract: This study investigated the beneficial effects of D-α-tocopherol supplementation in protecting against the renal morphological and functional changes caused by hypertension. Spontaneously hypertensive (SHR) and normotensive control (WKY) rats received D-α-tocopherol (80 mg/kg by gavage) or vehicle (mineral oil) every other day for 60 days, from the age of 2 months. After this treatment period, all animals were assessed for renal morphological and functional parameters. The glomerular hypertrophy, increased interlobular wall thickness and enlarged renal vascular resistance found in SHR were reduced by D-α-tocopherol treatment. Sodium and volume retention observed in SHR were also decreased by D-α-tocopherol treatment. Moreover, D-α-tocopherol supplementation significantly reduced arterial pressure in SHR but not in WKY. D-α-tocopherol also reduced the excretion of thiobarbituric acid-reactive substances (TBARS), a marker of oxidative stress, in SHR. These results suggest that D-α-tocopherol supplementation can reduce kidney damage induced by hypertension. O presente estudo avaliou os efeitos benéficos da suplementa o com D-α-tocopherol sobre as altera es morfológicas e funcionais renais causadas pela hipertens o arterial. A partir de dois meses de idade, ratos espontaneamente hipertensos (SHR) e controles normotensos (WKY) receberam D-α-tocoferol (80 mg/kg por gavagem) ou veículo (óleo mineral) em dias alternados, por 60 dias. Após este período foram avaliados os parametros morfofuncionais dos rins. Os animais SHR apresentaram: hipertrofia glomerular, aumento da espessura da parede das arterias interlobulares e eleva o da resistência vascular renal. Estas altera es foram menores nos animais SHR suplementados com D-α-tocoferol. A reten o de sódio e de volume encontrada nos SHR também foi reduzida com o tratamento com D-α-tocoferol. Além disso, a suplementa o com D-α-tocoferol reduziu significativamente a press o arterial em SHR, mas n o em WKY. Houve, também, redu o da excre o de ácido tiobarbitúrico (TBARS), um marcador de estresse oxidativo, nos animais SHR tratados com D-α-tocoferol. Os resultados sugerem que suplementa o com D-α-tocoferol é capaz de reduzir importantes altera es renais causadas pela hipertens o arterial.
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