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Cells 2013

Divergent Roles of Autophagy in Virus Infection

DOI: 10.3390/cells2010083

Abhilash I. Chiramel,Nathan R. Brady,Ralf Bartenschlager

Keywords: selectively autophagy, virophagy, antiviral and proviral autophagy

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Abstract:

Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and manipulate different host cell processes, including cellular trafficking, metabolism and immunity-related functions, for their own survival. In this article, we review evidence for how autophagy, a highly conserved cellular degradative pathway, serves either as an antiviral defense mechanism or, alternatively, as a pro-viral process during virus infection. Furthermore, we highlight recent reports concerning the role of selective autophagy in virus infection and how viruses manipulate autophagy to evade lysosomal capture and degradation.

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