On stromal-hematopoietic interrelationships. Maximow's ideas and modern models. Lecture at Wilsede Meeting 1988, Audio

AudioURL: http://www.science-connections.com/Wilsede-Activities/multimedia/audio.html#friedensteinDOI: 10.3205/wsc-2009-en-000041.01This transcript was prepared by Liudmila Lashkouskaya, René J. Hornung and ClaudiaKoltzenburg (Cellular Therapy and Transplantation, http://www.ctt-journal.com)URL: http://www.science-connections.com/books/other/On stromal-hematopoieticinterrelationships AJ Friedenstein 1988 Wilsede.pdfDOI: 10.3205/wsc-2009-en-000041.02License: Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported,http://creativecommons.org/licenses/by-nc-sa/3.0/Full article by the same author, on the same issue, with slides:Stromal-hematopoietic interrelationships: Maximov's ideas and modern modelsA. FriedensteinRepublished from Modern Trends in Human Leukemia VIII (1989), Ed. R. Neth, with kindpermission by Springer Science and Business MediaCellular Therapy and Transplantation (CTT), Vol. 1, No. 3, 2009doi: 10.3205/ctt-2009-en-000033.01http://www.ctt-journal.com/1-3-en-friedenstein-1989.html---------------------------[Introduction by Malcolm A.S. Moore]Malcolm A.S. Moore:Doctor Friedenstein is a person that I think laid the foundations for the substantial areas ofresearch that was carried out subsequently by other people, including Mike Dexter andmyself. We owe him a major debt for his pioneering work and it is particularly exciting for usto have him come to this meeting. It is one of… I think, talking to him, he said the secondtime that he has been outside the USSR at a scientific meeting.So we'll begin with the first talk: "On stromal-hematopoietic interrelationships. Maximow'sideas and modern models." - Doctor Friedenstein?Alexander Friedenstein:It's certainly an honour to speak here about Maximow's works in connection with modernproblems of hemopoietic micro-environment. It's also a great pleasure for me to participate inthis meeting. So I want to thank Doctor Neth for giving me the possibility to come to thismeeting.The idea of stromal-hemopoietic interactions was part of Maximow's theory of hemopoiesis,which he proposed more than 60 years ago. Maximow assumed that differentiation ofhemopoietical stem cell descendants depends on what he called "local conditions", which aregenerated from bone marrow stroma. Maximow's theory was far ahead of his time. Andthough Maximow was highly respected in the scientific community, his concept of localstromal conditions was met with skepticism. But now, this Maximow's idea raises no doubt. Itwas directly proved by Dexter cultures and in fact constitutes an essence of problem of thehemopoietic micro-env