Isotretinoin in acne therapy - dosage regimens with regard to efficacy, interactions, tolerance, safety and therapy costs Izotretynoina w tr dziku - schematy dawkowania w aspektach skuteczno ci,

Since its approval by the US Food and Drug Administration (FDA) in 1982, isotretinoin has been considered a breakthrough treatment against severe forms of acne. Systemic isotretinoin remains the most efficacious treatment for severe acne as well as many cases of more moderate disease that are unresponsive to other treatment modalities. Regardless of presence for approximately three decades on the market, there is still the question: which dosage? Moreover, isotretinoin is the only drug producing long-term remission, as well influencing scarring tendency. The current manuscript outlines the most appropriate dosage regimens for achieving the excellent efficacy, describes how to optimize treatment, reviews the recommended guidelines for treatment and monitoring, and summarizes interactions and adverse effects linked to oral isotretinoin usage.