Pro-inflammatory cytokines in etiology of acne vulgaris - rewiev of literature Cytokiny prozapalne w etiologii tr dziku pospolitego - przegl d pi miennictwa

Acne vulgaris is the most frequently diagnosed dermatosis in patients between 11 and 30. It is believed that it affects about 80% of persons in this age group or even, taking into account lesions of low intensity, 100% of young people. The role of cytokines in the pathogenesis of acne is not fully known. The rewiev of modern literature about the role of cytokines in etiology of acne and the influances of retinoids was presened in our study. The TLR2 receptors play the role in the etiology of acne. Stimulation of TLR2 by Propionibacterium acnes makes the IL-8 and IL-12 concentrations increase. Macrophages surrounding the pilosebaceous unit with TLR2 receptors were histologically described in biopsy materials of patients with acne. Using immunohistochemical methods, expression of IL-1α and β has been demonstrated within sebaceous glands.