In the recent era, diabetes mellitus has emerged as one of the significant threats to public health and this situation demands the attention of the researchers and allied stakeholders. Dietary regimens using functional and nutraceutical foods are gaining wide range of acceptance and some traditional medicinal plants are of considerable importance. The main objective of this instant study was to explore the antidiabetic potential of Nigella sativa fixed oil (NSFO) and essential oil (NSEO). Three experimental groups of rats received diets during the entire study duration, that is, D1 (control), D2 (NSFO: 4.0%), and D3 (NSEO: 0.30%). Experimental diets (NSFO & NSEO) modulated the lipid profile, while decreasing the antioxidant damage. However, production of free radicals, that is, MDA, and conjugated dienes increased by 59.00 and 33.63%, respectively, in control. On the contrary, NSFO and NSEO reduced the MDA levels by 11.54 and 26.86% and the conjugated dienes levels by 32.53 and 38.39%, respectively. N. sativa oils improved the health and showed some promising anti-diabetic results. 1. Introduction In the domain of diet-based therapies, functional foods are important to combat lifestyle related disorders, that is, hyperglycemia, high cholesterol, and immune dysfunction. Such functional foods, nutraceuticals, and pharma foods are modern trends [1] and utilization of medicinal plants is gaining wide range of recognition [2, 3]. Various plants rich in functional ingredients possess the ability to reduce hyperglycemia and hypercholesterolemia along with quenching free radicals [4]. The bioactive molecules present in them, including antioxidants, phytosterols, and flavonoids, are responsible for health claims associated with the plants. Recent research studies also validated some traditional health claims of certain plants and whole scenario led dietetics/nutritionists to consider them suitable in diet-based medication of various illnesses [5]. Diabetes mellitus is one of the leading causes of mortality all over the globe and targets multiorgan systems [6]. According to World Health Organization estimates, more than 376 million people will be diabetic globally in 2030 and about two billion people would be at risk due to poor dietary habits, obesity, and lack of physical exercise [7]. It is worth mentioning that healthy lifestyle and dietary measures can prevent 30–40% of all kinds of diseases. Diet diversification or slight changes in the daily diet can possibly prevent the onset of diabetes mellitus [8]. Therefore, the utilization of natural foods rich in
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