Introduction. This study aimed to report the characteristics, prognostic factors, and treatment outcomes of 54 patients with primary gastric lymphoma. Materials and Methods. This retrospective study was carried out by reviewing the medical records of 54 adult patients diagnosed at a tertiary academic hospital. All the patients were treated with curative intent. Forty-four patients (81.5%) underwent gastrectomy followed by adjuvant chemotherapy and/or radiotherapy, whereas 10 ones (18.5%) were treated with chemotherapy alone or with radiotherapy. Results. The study was conducted on 25 males and 29 females with the median age of 50 years. Diffuse large B-cell lymphoma (DLCL) (67%) and Mucosa Associated Lymphoid Tissue (MALT) lymphoma (26%) were the most common histologic types. Besides, 36 (59%), 16 (30%), 5 (9%), and 1 (2%) patients were in stages I, II, III, and IV, respectively. The 5-year disease-free survival and overall survival were 64.7% and 67%, respectively. In univariate analysis for overall survival, International Prognostic Index (IPI) ( ), the WHO performance status ( ), Ann Arbor stage ( ), age ( ), and LDH serum level ( ) were the prognostic factors. Conclusion. Gastric lymphoma tends to present in early stage of the disease and has a favorable outcome. 1. Introduction Primary gastric lymphomas are rare. Although their incidence rate is increasing, they comprise less than 10% of gastric malignancies. Despite this rarity, stomach accounts for more than two-third of all extranodal non-Hodgkin lymphomas. Because of its multiple subtypes and low prevalence, its treatment is not so clear cut. More than 30 types, with different biological and clinical characteristics, have been recognized by the WHO classification. Two main subtypes are MALT and DLCL with different behaviors and treatments. Other less frequent subtypes are follicular, mantle, and T-cell lymphoma [1–3]. Previously, the main treatment for gastric lymphomas was supposed to be surgery. Older studies pointed to the important role of surgery in treatment of the disorder [2, 4]. However, multiple retrospective and prospective studies in late 20th century showed that extend of surgery and even performing the surgery had no roles in gastric lymphoma outcome [2, 3]. Early stage MALT lymphomas are usually treated with antibiotics. Those who are negative for or resistant to H. pylori are treated with radiotherapy. Chemotherapy is also an effective therapeutic option. On the other hand, gastric DLCL is treated by chemotherapy and immunotherapy. Radiotherapy could be used for localized cases.
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