Present study was designed to obtain association between sleep apnea with sleep quality and quality of life in COPD patients. This cross-sectional descriptive study was conducted on 139 patients with COPD in a chest clinic of a university hospital. All patients were evaluated by pulmonary function test for determination of severity of their disease. Also, Berlin questionnaire, Epworth sleepiness scale, Pittsburgh Sleep Quality Index, and St. George Respiratory questionnaires (SGRQ) were employed for assessment of patients. Analysis of data showed that quality of sleep was significantly correlated with quality of life ( ). About half of the patients were at high risk for sleep apnea. The patients were divided into two groups according to the result of Berlin questionnaire. Significant differences were found between the groups for total score and each of three subscores of SGRQ suggesting worse quality of life in overlap syndrome ( ). Also, patients with overlap syndrome had worse quality of sleep compared to patients without it ( versus ; ). Stepwise multiple regression analysis showed that severity of COPD, coexisting obstructive sleep apnea, and sleep quality accounted for the SGRQ significantly ( (coefficient of determination) = 0.08, 0.21, and 0.18, resp.). It is recommended that patient with COPD be evaluated for sleep apnea and sleep disorders during routine examinations and followups. 1. Introduction Both chronic obstructive pulmonary disease and obstructive sleep apnea are common [1]. It is estimated that 5–15% of adult population suffers from COPD [2]. Also, obstructive sleep apnea (OSA) is prevalent in adults with 4% of men and 2% of women [3]. Then simultaneous presentation of them, that is, overlap syndrome, is not surprising [4]. Both diseases may affect sleep quality and quality of life. Chronic obstructive pulmonary disease may produce subjective and objective changes in sleep. The patients have difficulties in initiation and continuance of sleep and may complain from daytime sleepiness. Moreover, nocturnal drops in O2 saturation caused by COPD eventually may lead to pulmonary hypertension, cardiac arrhythmia, and night time arousal [5, 6]. The nocturnal drop in O2 saturation in patients with overlap syndrome may lead to the more severe daytime sleepiness, shorter sleep time, lower sleep efficiency and higher arousal index are expected. However, it is essential to note that hypoxia is one of the causes of these symptoms in the patients. Recent studies have demonstrated that quality of sleep is under influence of obstructive apnea rather
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