Geographical Flushing of the Children’s Face: A New Clinical Entity?

A lot of skin diseases can occur on children’s faces. We report two children with unique flushing on their faces, sometimes accompanied with headache. Their eruption did not meet various differential diagnoses. Many dermatologists may have seen a similar condition but did not think much about it. Thus, it should be worth regarding such symptom as the benign new clinical entity, which may comfort patients with similar conditions and merit further attention in clinical practice. 1. Introduction A lot of skin diseases can occur on children’s faces. Especially, we often see pediatric patients with a “red face” induced by, for example, urticaria, contact dermatitis, atopic dermatitis, or sunburn [1–4]. Recently, we experienced two children with unique flushing on the faces, sometimes accompanied with headache. Because their eruption did not meet various differential diagnoses, we suspect they may be a new clinical entity. 2. Case Report 2.1. Case 1 An 8-year-old Japanese boy visited our hospital, for the treatment of an eruption. One year ago, his parents had noticed multiple reddish macules on his face, when he exercised under the summer sun. Patchy multiple erythemas merged to be geographical (Figure 1), and only the face was involved. The severity of his eruption was proportional to the intensity of exercise, and the rash was sometimes accompanied with sweating and headache. He did not notice pruritus or respiratory distress, and his eruption always regressed spontaneously after about 30 minutes rest. Figure 1: Facial geographical erythemas of case . A clinical diagnosis of solar urticaria was made by an other pediatric clinic, and sunscreen and oral antihistamine drug were tried, but the symptom was not prevented. Then, he was suspected of having photosensitivity (i.e., xeroderma pigmentosum or porphyria) and was referred to our hospital. We could not find any other abnormalities indicating photosensitivity: minimal response dose by UVA and minimum effective dose by UVB were within normal limits. There was no record of any similar condition in his family history nor did he have an allergy. The patient is currently observed without any treatment, but the symptom did not affect his daily lifes and there have been no other severe problems. 2.2. Case 2 An 8-year-old Japanese boy suffered from an eruption during exercise in summer 2 years ago. The eruption was patchy multiple erythemas (Figure 2), sometimes accompanied with sweating and headache. The eruption disappeared without pigmentation or scar after 30 minutes. He was carefully observed without