Primary Pleomorphic Liposarcoma of Liver: A Case Report and Review of the Literature

Primary liver liposarcoma is a rare disease. The knowledge of the clinical course, management, and prognosis of primary liver liposarcoma are all limited because of its rarity. Twelve cases of primary liposarcoma of the liver have been previously reported. We present the thirteenth case, which occurred in an adult male patient. A 42-year-old male patient came to our outpatient department with complaints of pain abdomen, mass per abdomen, and weight loss. Ultrasonography showed a mass arising from the the left lobe of liver. CT abdomen showed a heterogenous enhancing mass from left lobe of liver with multiple cystic and necrotic areas compressing the stomach and spleen with no evidence of metastasis. Differential diagnosis included adenoma and primary malignancy. Exploratory laparotomy and resection were done. HPE was found to be pleomorphic liposarcoma of liver. 1. Introduction Virchow first described a malignant tumor of fatty tissue arising in the lower extremity in 1857 [1]. Since then, liposarcomas have been identified in a number of tissue and organs, but only rarely in the liver. The most common sites are the deep soft tissue of the trunk, retroperitoneum, and the subcutaneous fat of the upper and lower extremities [2]. Liposarcoma itself constitutes about 9.8% to 18% of soft tissue sarcomas; its incidence is second only to that of Malignant Fibrous Histiocytoma (MFH) [3]. The experience in dealing with this malignant neoplasm is limited because of its rarity. Primary liposarcoma of the liver must be considered in the differential diagnosis of a hepatic mass that develops in a noncirrhotic liver in whom liver transplantation may be considered as liposarcoma is clearly an absolute contraindication for liver transplantation [4]. Hepatic resections might be efficient although prognosis is poor and recurrence is more. Furthermore, most of the articles describing liver liposarcoma concentrate only on histopathological and imaging studies. The clinical course and prognosis of primary liver sarcoma are rarely mentioned. Hence we report a case of liposarcoma liver in detail. 2. Case Report A 42-year-old male patient had history of pain abdomen which he attributed to a mass per abdomen noticed since 15 days. Pain was intermittent, dull aching variety with symptom-free intervals. He also complained of weight loss. On examination, a mass of size approximately ？cm was felt occupying the epigastrium and left hypochondrium. All the blood tests were normal. Chest X ray revealed elevation of left hemidiaphragm and Ultrasonography revealed a large heterogenous