全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Advanced Ovarian Dysgerminoma Infiltrating Both Ovaries and Uterus in a 7-Year-Old Girl

DOI: 10.1155/2014/910852

Full-Text   Cite this paper   Add to My Lib

Abstract:

Introduction. Ovarian dysgerminoma is a rare malignant ovarian germ cell tumor with its peak incidence in young women. Abdominal pain, abdominal distention, and the presence of a palpable mass are common symptoms at presentation. Depending on the FIGO stage at presentation the prognosis of dysgerminomas after surgical treatment, adjuvant chemotherapy, and radiotherapy is promising. Case Presentation. A 7-year-old girl was presented at our clinic with abdominal pain in all abdominal quadrants. Later the pain localized in the region of her right ovary. CT scan revealed a massive formation which was connected to her right ovary. Conclusion. Although malignant ovarian germ cell tumours are rare in children, physicians must always consider the possibility of MOGT-occurrences. The clinical symptoms might not be specific: abdominal pain, abdominal distention, nausea, and vomiting. In order to make a correct diagnosis the patients should undergo a complete clinical examination including radiological scans. Initial management is frequently surgery, followed by adjuvant chemotherapy and radiotherapy. Although disgerminoma is malignant tumor, the prognosis is promising. 1. Introduction Dysgerminoma is a rare malignant ovarian germ cell tumor (MOGT) which is highly malignant and has its peak incidence in young women. Approximately one-third of all dysgerminomas show KIT mutations and these are associated with advanced stage at presentation [1]. Clinically the patients present with abdominal pain, abdominal distention, and presence of a palpable mass, reduced appetite, vomiting, and nausea as well as ovarian torsion [2, 3]. Conservative surgery, postoperative chemotherapy, and postoperative radiotherapy are effective therapeutic options. Fertility-preservation surgery is often possible [3] and the overall survival is 92.4% [4]. Preoperative elevation of tumor markers is significantly related to poor prognosis for progression-free survival (PFS) [4]. Dysgerminomas reveal in 28% of cases presence of lymph node metastasis, which is significantly associated with lower 5-year survival (82.8%) [5]. Older patients were more likely to be diagnosed at an advanced stage [6]. 2. Case Presentation We report the case of a 7-year-old Albanian girl who was presented with abdominal pain and a palpable mass in the region of her right ovary. Initially the girl complained about abdominal pain in all quadrants of the abdomen. Later the pain was localized on the right side. According to her mother the pregnancy with her daughter was uncomplicated; the girl had never been ill before, had

References

[1]  L. Cheng, L. M. Roth, S. Zhang et al., “KIT gene mutation and amplification in dysgerminoma of the ovary,” Cancer, vol. 117, no. 10, pp. 2096–2103, 2011.
[2]  S.-M. Chu, Y.-C. Ming, H.-C. Chao et al., “Ovarian tumors in the pediatric age group: 37 cases treated over an 8-year period,” Chang Gung Medical Journal, vol. 33, no. 2, pp. 152–156, 2010.
[3]  D. Biswajit, C. N. Patil, and T. G. Sagar, “Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients,” Journal of Pediatric Hematology/Oncology, vol. 32, no. 2, pp. e54–e56, 2010.
[4]  S. Tangjitgamol, J. Hanprasertpong, S. Manusirivithaya, V. Wootipoom, T. Thavaramara, and R. Buhachat, “Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes,” Acta Obstetricia et Gynecologica Scandinavica, vol. 89, no. 2, pp. 182–189, 2010.
[5]  S. Kumar, J. P. Shah, C. S. Bryant et al., “The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary,” Gynecologic Oncology, vol. 110, no. 2, pp. 125–132, 2008.
[6]  E. Drozyńska, K. Po?czyńska, S. Popadiuk, et al., “Characteristics of extracranial malignant germ cell tumours in two age groups of children (0–10 and 10–18 years). Multicentre experiences,” Medycyna Wieku Rozwojowego, vol. 15, no. 1, pp. 16–24, 2011.
[7]  M. M. Andrés, E. Costa, A. Ca?ete, L. Moreno, and V. Castel, “Solid ovarian tumours in childhood: a 35-year review in a single institution,” Clinical and Translational Oncology, vol. 12, no. 4, pp. 287–291, 2010.
[8]  D. Vicus, M. E. Beiner, S. Klachook, L. W. Le, S. Laframboise, and H. Mackay, “Pure dysgerminoma of the ovary 35 years on: a single institutional experience,” Gynecologic Oncology, vol. 117, no. 1, pp. 23–26, 2010.
[9]  S. Nishio, K. Ushijima, A. Fukui et al., “Fertility-preserving treatment for patients with malignant germ cell tumors of the ovary,” Journal of Obstetrics and Gynaecology Research, vol. 32, no. 4, pp. 416–421, 2006.
[10]  A. Quero-Hernández, R. Estrada-Correa, H. Tenorio-Rodríguez, and R. M. Alvarez-Solís, “Malignant germ cell ovarian tumors: clinical characteristics, treatment and outcome,” Cirugia Y Cirujanos, vol. 75, no. 2, pp. 81–85, 2007.

Full-Text

Contact Us

[email protected]

QQ:3279437679

WhatsApp +8615387084133