A consumer satisfaction study was conducted to examine the effectiveness on hangover of After-Effect？, a new food supplement dedicated to improve well-being after an occasion of alcohol consumption. persons were invited to participate in a home-based open label study to test the effectiveness of After-Effect？. On a night when they intended to consume alcohol, three pills were taken before alcohol consumption and two pills afterwards, before going to bed. The following day, participants completed a survey on the amount of alcohol consumed, hangover symptom severity, and satisfaction of the product. participants completed the study. 88% of participants reported After-Effect？ to be effective in reducing alcohol hangover. After-Effect？ significantly improved overall hangover severity, and all individual hangover symptoms, except for palpitations. In addition, a significant reduction ( ) in the severity score on concentration problems was reported when using After-Effect？. No gender differences were observed, and there was no relationship with the number of alcoholic drinks that were consumed. Consumers were satisfied with the product. In conclusion, consumer satisfaction and hangover severity scores suggest that After-Effect？ may be effective in reducing alcohol hangover. However, controlled, double-blind clinical trials should confirm these findings. 1. Introduction Alcohol hangovers are the most commonly reported negative consequence of heavy drinking. About 80% of drinkers acknowledge having experienced a hangover at least once during the past year [1], a finding that is corroborated by clinical trials indicating that around 20% of drinkers are resistant to hangover [2]. Alcohol hangovers are characterized by a feeling of general misery, and several symptoms such as headache, thirst, sleepiness, and concentration problems are commonly reported [3]. The aftereffects of alcohol consumption experienced during hangover are often qualified as unpleasant and disabling. For example, subjects report missing classes, work, or other obligations due to hangovers, but also feelings of regret and mood changes may be the result of excessive alcohol consumption [3]. Hence, there is a clear need for a treatment or cure that prevents or reduces hangovers. On the Internet, many cures are marketed, but a systematic literature search revealed that the efficacy of the vast majority of them has not been scientifically investigated [4, 5]. Up to now, most potential hangover cures have shown no effectiveness, whereas other cures reduced only some of the core symptoms of alcohol
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