Virtually, all studies reporting the outcomes of living kidney donation beyond the first year from donation were retrospective. In this prospective study, the outcome of 81 consecutive living kidney donors was thoroughly evaluated. Clinical, laboratory, and radiological assessments were carried out at predonation (basal), 3, 6, 12, and 24 months after donation. The mean age at time of donation was 37.8 ± 9.8 years and the majority was females (75.3%). The mean BMI increased significantly after donation ( ). The mean serum creatinine levels (mg/dl) were 0.75 ± 0.14, 1.01 ± 0.22, 0.99 ± 0.21, 0.98 ± 0.20, and 0.94 ± 0.20 ( ). Likewise, the mean levels of measured creatinine clearance (mL/min) were 148.8 ± 35.7, 94.7 ± 26.6, 95.5 ± 24.6, 96.7 ± 20.2, and 101.6 ± 26.2 ( ). The mean 24 hours urinary protein excretion (gm/dL) were 0.09 ± 0.03, 0.19 ± 0.18, 0.16 ± 0.09, 0.18 ± 0.25, and 0.17 ± 0.12 ( ). There were significant increases in the means of the longitudinal and transverse diameters of the remaining kidney over time ( ). Out of 42 female donors, eleven female donors have got successful postdonation pregnancies. There were no reported surgical complications, either intra- or postoperative. Long-term follow-up is necessary for all living kidney donors through local institutional and world registries. This trial is registered with ClinicalTrials.gov NCT00813579. 1. Introduction Living donor kidney transplantation is the treatment of choice for patients with end-stage renal failure for several reasons. The transplant is performed when the donor and the recipient are in optimum medical condition and at a time that is convenient for them and for their families. Moreover, recipients of living donor kidney grafts enjoy greater long-term graft survival and a better quality of life than do recipients of cadaveric kidney grafts [1]. It reduces the number of patients on the wait list for a cadaveric kidney and therefore increases the likelihood that patients with no potential living donor can undergo transplantation. This is particularly important because the gap between the number of cadaveric donors and the number of patients on the waiting list is increasing due to significant reduction in traffic accidents as well as the promotion of more healthy lifestyles with emphasis on exercise and improved dietary habits and the subsequent reduction in the incidence of stroke [2]. An increase in the number of living donors (including living-unrelated donors) may ameliorate this trend [3]. Almost all studies that report medical outcomes of living kidney donors more than
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