Pleomorphic Hyalinizing
Angiectatic Tumor (PHAT) is a rare mesenchymal neoplasma. It is a pathological
term describing a heterogeneous group of neoplasms of undetermined tumorigenesis
and undefined malignancy. Based only on the morphological findings of
histopathology, the biological potential of the tumor is indeterminate.
Determination of glucose metabolism using FDG-PET revealed mildly increased FDG
uptake in the tumor. We propose that FDG accumulation in the ectatic vessel,
increased uptake of the pleomorphic cells and/or associated inflammatory cells,
and increased permeability of the stroma lead to the imaging feature.
References
[1]
M. E. Smith, C. Fisher and S. W. Weiss, “Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts. A Low-Grade Neoplasm Resembling Neurilemoma,” American Journal of Surgical Pathology, Vol. 20, No. 1, 1996, pp. 21-29. http://dx.doi.org/10.1097/00000478-199601000-00002
[2]
Q. Ke, Erbolat, H. Y. Zhang, H. Bu, S. Li, D. N. Shi, et al., “Clinocopathology Features of Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts,” Chinese Medical Journal, Vol. 20, No., 2007, pp. 876-881.
[3]
H. C. Peng, M. T. Huang, D. J. Chen, T. K. Leung and J. S. Chu, “Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts,” Journal of the Formosan Medical Association, Vol. 109, No. 8, 2010, pp. 616-620. http://dx.doi.org/10.1016/S0929-6646(10)60100-3
[4]
A. L. Folpe and S. W. Weiss, “Pleomorphic Hyalinizing Angiectatic Tumor: Analysis of 41 Cases Supporting Evolution from a Distinctive Precursor Lesion,” American Journal of Surgical Pathology, Vol. 28, No. 11, 2004, pp. 1417-1425. http://dx.doi.org/10.1097/01.pas.0000141406.02581.fb
[5]
S. Wei, Z. Pan, G. P. Siegal, T. S. Winokur, A. J. Carroll and D. Jhala, “Complex Analysis of a Recurrent Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts,” Human Pathology, Vol. 43, No. 1, 2012, pp. 121-126. http://dx.doi.org/10.1016/j.humpath.2011.02.023
[6]
M. Machan and V. Konkovic-Capin, “Fordyce’s Angiokeratomas,” The New England Journal of Medicine, Vol. 366, 2012, p. 1240. http://dx.doi.org/10.1056/NEJMicm1104749
[7]
S. Basu, T. Chryssikos, S. Moghadam-Kia, H. Zhuang, D. A. Torigian and A. Alavi, “Positron Emission Tomography as a Diagnostic Tool in Infection: Present Role and Future Possibilities,” Seminars in Nuclear Medicine, Vol. 39, No. 1, 2009, pp. 36-51. http://dx.doi.org/10.1053/j.semnuclmed.2008.08.004
[8]
C. H. Hsu, C. M. Yang and C. H. Cheng, “Angiolipoma Detected by F-18 FDG Positron Emission Tomography,” Clinical Nuclear Medicine, Vol. 28, No. 7, 2003, pp. 604-605. http://dx.doi.org/10.1097/00003072-200307000-00019
[9]
C. H. Hsu, C. M. Lee, F. C. Wang and C. L. Fang, “Neurofibroma with Increased Uptake of F-18-Fuloro-2 Deoxy-D-Glucose Interpreted as a Metastatic Lesion,” Annals of Nuclear Medicine, Vol. 17, No. 7, 2003, pp. 609-611. http://dx.doi.org/10.1007/BF03006677
[10]
C. H. Hsu, C. M. Lee and S. Y. Lin, “Inflammatory Pseudotumor Resulting From Foreign Body in Abdominal Cavity Detected by FDG PET,” Clinical Nuclear Medicine, Vol. 28, No. 10, 2003, pp. 842-844. http://dx.doi.org/10.1097/01.rlu.0000090933.66898.d4
[11]
M. Y. Choong, P. Z. Ke, C. Y. Huang and T. S. Li, “Pleomorphic Hyalinizing Angiectatic Tumor in the Inguinal area: A Potential Diagnostic Pitfall,” The American Surgeon Journal, Vol. 78, No. 1, 2012, pp. E45-46.
[12]
T. K. Subhawong, A. P. Subhawong, E. A. Montgomery and L. M. Fayad, “Pleomorphic Hyalinizing Angiectatic Tumor: Imaging Finding,” Skeletal Radiology, Vol. 41, No. 12, 2012, pp. 1621-1626. http://dx.doi.org/10.1007/s00256-012-1443-0
