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外周血可溶性CD28含量与Graves疾病的相关性研究
Correlation Analysis of Concentration of Plasma Soluble CD28 and Graves Disease

DOI: 10.12677/IS.2014.22003, PP. 11-16

Keywords: Graves病,可溶性CD28分子,相关性
Graves’ Disease
, Soluble CD28, Correlation

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Abstract:

目的:探讨Graves病患者外周血中可溶性CD28分子浓度与FT3FT4sTSHTRAb等实验室参数的相关性,以分析外周血可溶性CD28分子含量测定对Graves病的临床辅助诊断价值。方法:采用双单抗夹心酶联检测法分析Graves病患者血液中可溶性CD28分子的含量;化学发光免疫法检测血液中甲状腺功能指标FT3FT4sTSH的浓度;ELISA法测定血液中TRAb的含量。结果:Graves病人血液中可溶性CD28分子含量(3.42 ± 0.74 ng/ml)明显高于健康对照组(0.83 ± 0.29 ng/ml) (p < 0.01);患者体内可溶性CD28分子的表达水平与FT3FT4TRAb浓度均呈正相关关系,相关系数γ分别为0.7860.746
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