Background: Previous studies reported that non-small cell carcinoma
patients characterized by female gender, never-smoking status and
adenocarcinoma histology were more likely to harbor epidermal growth factor
receptor (EGFR) mutations. However, some studies failed to find the relationship
between EGFR mutation and gender. Methods: One hundred and eighty-four
consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were
studied retrospectively. Since the smoking rate is significantly higher in men,
we assumed that gender difference might be a seeming factor affected by
smoking. Therefore we subdivided the patients into 2 groups: never- and ever-smokers.
Results: The number of ever-smokers was 94.44% in men, whereas 8.51% in women.
EGFR mutation was positive in 48.9%. For overall patients, EGFR mutation status
was associated with gender, pStage, pT status, lepidic dominant histologic
subtype, pure/mixed groundglass opacity (GGO) on computed tomography (CT) and
smoking status. However, in ever-smokers, EGFR mutation status was associated
with lepidic histologic subtype and GGO on CT, but not others including gender.
Similar results were also found in never-smokers, and gender was not also related
to EGFR mutation in never smokers.Conclusion: The EGFR mutational frequency among men and women was not
significantly different when lung adenocarcinoma patients were stratified into
never- and ever-smokers.
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