In a series of papers under the common title: “Analytical Methods in Quality Control of Scientific Publications,” cases of undisputable breaches of publication ethics and breaches of acceptable rules in the publication of scientific information have been presented. Clear cases of fraud, falsification by some authors, and unqualified review of papers by reviewers and editors were presented in: Analytical Methods in Quality Control of Scientific Publications, (2012) American Journal of Analytical Chemistry, Vol. 3, No. 6, pp. 443-447 DOI:10.4236/ajac.2012.36058. The place of authors, reviewers, editors, and publisher was discussed in: Editorial: Analytical Methods in Quality Control of Scientific Publications Part II: The Authors’, Reviewers’, Editors’ Responsibility, and the Publishers’ Authority, (2013) International Journal of Analytical Mass Spectrometry and Chromatography, Vol. 1, No. 2, pp. 81-89 http://dx.doi.org/10.4236/ijamsc.2013.12010, Analytical Methods in Quality Control of Scientific Publications Part III: Publishers’ Ethics and Editors’ Com- plicity, (2014) International Journal of Analytical Mass Spectrometry and Chromatography, Vol. 2, No. 3, pp. 77-102. DOI: 10.4236/ijamsc.2014.23008 and in the book Historical Overview of Chromatography and Related Techniques in Analysis of Antimalarial Drug Primaquine (Editor, Ilia Brondz) Nova Science Publishers, Inc., (2011) ISSN 978-1-61761-944-1. Here, the corrupting influence of the pharmaceutical industry as a customer and employer of pseudoresearchers and corrupt editors and even to corrupt journal publishers for publication of fraudulent information and pseudoscientific data will be discussed by identifying the authors of pseudoscientific publications, the editors who gave the green light for the fraudulent publication, and the pharmaceutical companies involved. Documentation will be given to support the accusations of fabricated fraudulent “scientific” data, and the publication of such data without sufficient revision and sufficient background for publication of papers will be illustrated by discussing the content of papers: “Determination of Quinocide as Impurityin Primaquine Tablets by Capillary Zone Electrophoresis,” Abdalla A. Elbashir et al., (2009) Biomedical Chromatography, Vol. 23, pp. 464-471, published in Wiley Interscience, “Development of a Capillary Electrophoresis Method for the Enantioselective Estimation of Primaquine in Pharmaceutical Formulations,” Abdalla A. Elbashir et al., (2008) Journal of AOAC International, Vol. 91, No. 3, pp. 536-541,
References
[1]
Brondz, I. and Brondz, A. (2012) The Technology for Preparation of Generic (Monoenantiomeric) Antimalarial Drug Primaquine by Using Supercritical Fluid Chromatography. Separation of Primaquine from Quinocide: Simultaneous Resolution of the Enantiomers of Primaquine and Their Separation from Quinocide in One Run. American Journal of Analytical Chemistry, 3, 884-890. http://dx.doi.org/10.4236/ajac.2012.312A117
[2]
Brondz, I. (2011) Historical Overview of Chromatography and Related Techniques in Analysis of Antimalarial Drug Primaquine (Editor Ilia Brondz). Nova Science Publishers, Inc., New York.
[3]
Elbashir, A.A., Saad, B., Ali, A.S.M., Saleha, M.I. and Aboul-Enein, H.Y. (2009) Determination of Quinocide as Impurity in Primaquine Tablets by Capillary Zone Electrophoresis. Biomedical Chromatography, 23, 464-471.
http://dx.doi.org/10.1002/bmc.1137
[4]
Elbashir, A.A., Saad, B., Ali, A.S.M., Saleha, M.I. and Aboul-Enein, H.Y. (2008) Development of a Capillary Electrophoresis Method for the Enantioselective Estimation of Primaquine in Pharmaceutical Formulations. Journal of AOAC International, 91, 536-541.
[5]
British Pharmacopoeia (1988) Vol. I, HMSO, London, 462.
[6]
British Pharmacopoeia (1988) HMSO, London, 1252.
[7]
British Pharmacopoeia (1993) Vol. I, HMSO, London, 541.
[8]
European Pharmacopoeia (1997) 3rd Edition, Council of Europe, Strasbourg, 1385.
[9]
British Pharmacopoeia (1993) London, HMSO, (Addendum) 2015.
[10]
British Pharmacopoeia (2000) Vol. I, HMSO, London, 1285.
[11]
Council of Europe (2001) European Pharmacopoeia. 3rd Edition, Council of Europe, Strasbourg, 1323.
[12]
Brondz, I., Mantzeilas, D., Klein, U., Lebedeva, M.N., Mikhailitsyn, F.S., Souleimanov, G.D. and Ekeberg, D. (2003) The Main Contaminant of the Anti-Malaria Drug Primaquine Is Its Positional Isomer. 3rd International Symposium on Separation in BioSciences SBS 2003 A 100 Years of Chromatography, Abstr. P-57, Moscow, 13-18 May 2003, 165.
[13]
Brondz, I., Mantzilas, D., Klein, U., Ekeberg, D., Hvattum, E., Lebedeva, M.N., Mikhailitsyn, F.S. and Souleimanov, G.D. (2004) Nature of the Main Contaminant in the Anti-Malaria Drug Primaquine Diphosphate: A Qualitative Isomer Analysis. Journal of Chromatography B: Biomedical Sciences and Applications, 800, 211-223.
[14]
Jia, H. (2014) GSK Fined ￡300 Million for China Corruption. Journal of Chemical Education, 25 September 2014.
http://www.rsc.org/chemistryworld/2014/09/gsk-fined-300million-china-corruption
[15]
Bradsher, K. and Buckleysept, C. (2014) China Fines GlaxoSmithKline Nearly $500 Million in Bribery Case. The New York Times, 19 September 2014.
http://www.nytimes.com/2014/09/20/business/international/gsk-china-fines.html?_r=0
[16]
Grant, B. (2009) Elsevier Published 6 Fake Journals. The Scientist, 7 May 2009.
http://www.the-scientist.com/?articles.view/articleNo/27383/title/Elsevier-published-6-fake-journals/
[17]
Grant, B. (2009) Merck Published Fake Journal. The Scientist, 30 April 2009.
http://www.the-scientist.com/?articles.view/articleNo/27376/title/Merck-published-fake-journal/
[18]
Brondz, I. (2012) Analytical Methods in Quality Control of Scientific Publications. American Journal of Analytical Chemistry, 3, 443-447. http://dx.doi.org/10.4236/ajac.2012.36058
[19]
Brondz, I. (2013) Analytical Methods in Quality Control of Scientific Publications Part II: The Authors’, Reviewers’, Editors’ Responsibility and the Publishers’ Authority. International Journal of Analytical Mass Spectrometry and Chro- matography, 1, 81-89. http://dx.doi.org/10.4236/ijamsc.2013.12010
[20]
Brondz, I. (2014) Analytical Methods in Quality Control of Scientific Publications Part III: Publishers’ Ethics and Editors’ Complicity. International Journal of Analytical Mass Spectrometry and Chromatography, 2, 77-102.
http://dx.doi.org/10.4236/ijamsc.2014.23008
[21]
Brondz, I., Klein, U., Ekeberg, D., Mantzilas, D. and Hvattum, E. (2004) Nature of the Main Contaminant in the Anti- Malaria Drug Primaquine Di-Phosphate: GC-MS Analysis. International Symposium Analytical Forum, Warsaw, 4-8 July 2004, Abstract P Tu11/P48, 154.
[22]
Brondz, I., Klein, U., Ekeberg, D., Mantzilas, D., Hvattum, E., Schultz, H. and Mikhailitsyn, F.S. (2005) Nature of the Main Contaminant in the Anti-Malaria Drug Primaquine Diphosphate: GC-MS Analysis. Asian Journal of Chemistry, 17, 1678-1688.
[23]
Brondz, I. and Klein, U. (2005) Separation of the Positional Isomer Quinocide from the Anti-Malarial Drug Primaquine Using a Discovery? HS F5 HPLC Column. The Reporter, 23, 1.
[24]
Brondz, I., Ekeberg, D., Karaliova, L., Jennings, I., Hustad, J.A. and Svendsen, R. (2005) Separationof the Positional Isomer Quinocide from the Anti-Malaria Drug Primaquine Using a Discovery? HS F5 HPLC Column. Trends in Chro- matography, 1, 78-81.
[25]
Brondz, I., Klein, U., Karaliova, L., Vlachos, V., Oakley, P., Leideborg, R. and Mikhalitsyn, F. (2005) Nature of the Main Contaminant in the Drug Primaquine Diphosphate: Comparison of HPLC and SFC Methods. 29th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Stockholm 26-30 June 2005, Abstract 12: 43, 430.
[26]
Brondz, I., Ekeberg, D., Bell, D.S., Hustad, J.A., Svendsen, R., Vlachos, V., Oakley, P., Langley, G.J., Mohini, T., Amaury, C.G. and Mikhalitsyn, F. (2007) Nature of the Main Contaminant in the Drug Primaquine Diphosphate: SFC and SFC-MS Methods of Analysis. Journal of Pharmaceutical and Biomedical Analysis, 43, 937-944.
http://dx.doi.org/10.1016/j.jpba.2006.09.017
[27]
Brondz, I., Ekeberg, D., Annino, A.R. and Palcic, T. (2007) SFC-MS Analyses of Anti-Malaria Drug Primaquine Diphosphate. Comparison of Techniques and Instrumentation. 12th Norwegian MS-Winter Meeting, Hafjell, 21-24 January 2007, Abstract p. 42.
[28]
Brondz, I., Fialkov, A.B. and Amirav, A. (2009) Analysis of Quinocide in Unprocessed Primaquine Diphosphate and Primaquine Diphosphate Tablets Using Gas Chromatography-Mass Spectrometry with Supersonic Molecular Beams. Journal of Chromatography A, 1216, 824-829. http://dx.doi.org/10.1016/j.chroma.2008.11.043
[29]
Brondz, I. (2009) SFC-MS Analysis of Contaminants in Primaquine Diphosphate Tablets and Spectral UV and NMR Characterizing of Primaquine and Quinocide. In: Csizmadia, E. and Kalnoky, I., Eds., Antimalarial Drugs: Costs, Safety and Efficacy, Nova Science Publishers, Inc., New York, 105-124.
[30]
Brondz, I. (2009) Improved Separation of Quinocide in Primaquine Analysis by Supercritical Fluid Chromatography- Mass Spectrometry. 5th Conference Nordic Separation Science Society, Abstr. P-06, Tallinn, 26-29 August 2009, Abstract PP07, 81.
[31]
Brondz, I. (2010) Historical Overview of Chromatography and Related Techniques in Analysis of Antimalarial Drug Primaquine. In: Quintin, T.J., Ed., Chromatography: Types, Techniques and Methods, Nova Science Publishers, Inc., New York, 281-322.
[32]
Brondz, I. (2011) In Vitro Techniques in Analysis of Antimalarial Drug Primaquine (Historical Overview of Chromatography and Related Techniques in Analysis of Antimalarial Drug Primaquine). 7th Annual BioMalPar Conference on the Biology and Pathology of the Malaria Parasite, Abstr. P-54, Heidelberg, 16-18 May 2011, 80.
