Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Objective: ？Diabetics are more susceptible to the infections than the non-diabetics (healthy) one, suggesting that the immunologic capability may be unbalanced in diabetics. Periodontitis is associated with alterations in immune responses in both diabetic and non-diabetic subjects. Till date various attempts has been taken to monitor host immunological response of diabetic individuals. Therefore the need to study the local immune response in inflamed gingival showing Periodontitis is apparent. Since till date there are no well documented and significant baseline studies are available on the functional capacities of the lymphoid cells present in gingiva of the periodontitis patients, a study to check the level of immunoglobulin was investigated. ？ Methodology: ？A study was carried out where HbA1c, Random Blood Sugar and Serum IgA level were assessed in 60 patients from the OPD of RCDSR. 15 patients each belonging to the four groups diabetic with periodontitis, diabetic without periodontitis, non-diabetic with periodontitis and non- diabetic without periodontitis (control) were analysed for the quantitative estimation of Serum Immunoglobulin A by Turbidometric Immunoassay and HbA1c was done by using Nyco card Reader. Result: The data thus obtained were compared with the level of immunoglobulin found in clinically healthy gingival of the control group. The levels of IgA were found to be high in group ‘A’ (Diabetic patients suffering from Periodontitis) group ‘B’ (Diabetic patients not suffering from Periodontitis) and group ‘C’ (Non-diabetic patients suffering from Periodontitis) but the values are not differing statistically from each other. But, the values of all these groups are statistically highly differed from the value obtained against the normal/healthy controlled group ‘D’. ？ Conclusion: ？In our study it can be concluded that there was positive co-relation between the two parameters: elevated HbA1c and Immunoglobulin level with periodontitis. This co-relates to the possibility of an underlying immuno-inflammatory abnormality to be the cause for the elevated level of immunoglobulin in our patients with elevated sugar level. DOI: http://dx.doi.org/10.3126/ajms.v6i2.11096 Asian Journal of Medical Sciences Vol.6(2) 2015 72-77