OALib Journal期刊
具有肝靶向潜力的马蹄金素衍生物合成及抗乙肝活性研究有机化学
DOI: 10.6023/cjoc201505011
Keywords: 肝靶向 ,马蹄金素衍生物 ,合成 ,抗HBV活性
Abstract:
为了提高马蹄金素(MTS)衍生物在肝脏病变部位的药物浓度,增强其抗乙肝病毒活性,设计并合成了5个半乳糖糖基化修饰的具有肝靶向潜力的MTS衍生物,通过1HNMR,13CNMR,1H-1HCOSY,HMQC和ESI-MS对其进行了结构表征,并用HepG22.2.15细胞模型初步评价了合成所得目标化合物的抗乙肝病毒(HBV)活性.结果表明,所有目标化合物对HBVDNA的复制均有抑制作用,且具有一定的量效关系.
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