Pathologic Features of Beh？et's Disease in the Tubuler Gut

Beh？et's disease (BD) is a vasculitic disorder of relapsing acute inflammation characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin lesions. The disease also affects other organs, including joints, the nervous system, blood vessels, and gastrointestinal (GI) system may also be involved and the lower GI tract is the mostly involved part, leading to severe morbidity. The frequency of GI involvement in BD varies among different ethnic groups. Although 50–60% of Japanese patients have GI disease, these manifestations are rare in patients from Mediterranean countries. The gastrointestinal manifestations of BD usually appear 4.5–6 years after the onset of the oral ulcers. The intestinal lesions are usually resistant to medical treatment and recur after surgery. The elementary lesion is apthous ulcer. Deep, round or oval ulcers with a punched-out appearance tend to perforate easily, so that many patients require urgent operation. 1. Introduction Beh？et’s Disease (BD) is a chronic rheumatic disease, in which unpredictable inflammatory episodes of orogenital and ocular inflammation (or ulceration) are induced by the body’s overreactive immune system, was first reported in 1937 by Hulusi Beh？et. Patients with incomplete form of Beh？et’s syndrome without ocular involvement, according to Morita et al., had been well described in the Japanese population [1]. Countries with a high prevalence of BD cluster along the ancient silk road from Eastern Asia to the Mediterranean Basin. Young adults between the second and fourth decades of life are mainly affected [2]. In children, this type of BD occurs very rarely, usually as the perianal aphthous lesions that appear to be a specific feature of childhood BD [3]. Beh？et’s disease is more common and more severe in men than in women in the ancient Silk Road countries, whereas in Western Europe and the USA, it is equivalent between the sexes or more common in women [2]. Populations has yielded interesting epidemiological findings: Turkish individuals who have emigrated to Germany have a significantly lower risk of disease than individuals of Turkish origin living in Turkey, although their risk remains higher than that of the native German population. The most plausible environmental trigger is an infectious agent, for that reason evidence of viral infection has been sought. Increased rates of anti-Saccharomyces cerevisiae antibodies (ASCAs); which are recently proposed serologic markers of disease and commonly associated with Crohn’s disease (CD), were previously reported by several studies in BD [4].