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超极化Xenon对慢阻肺的可视化加权成像Hot!

DOI: 10.11938/cjmr20150209, PP. 261-272

Keywords: 超极化氙气,磁共振成像,,表面扩张系数,慢阻肺

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Abstract:

超极化气体3He或者129Xe扩散加权成像已经被证明了能够有效检测慢性阻塞性肺部疾病(COPD)中肺部微结构的改变.相比于3He,129Xe更便宜而且更容易获得,但是129Xe成像中较低的信噪比致使129Xe的肺部表面扩散系数(ADC)的测量面临着许多困难.在该研究中,为了得到更高的图像信噪比,作者对气球模型,健康大鼠和COPD大鼠进行了单个b值(14cm2/s)的扩散加权超极化129Xe磁共振成像(MRI).所有的COPD模型大鼠是通过烟熏和注射内毒素(LPS)进行诱导得到的.在7T磁共振成像仪上面获得了大鼠肺实质的超极化129XeADC值分布图.COPD大鼠肺实质的129XeADC值是0.04422±0.0029和0.04234±0.0023cm2/s(Δ=0.8/1.2ms),远大于健康大鼠肺实质的129XeADC值0.0377±0.0023和0.0367±0.0013cm2/s.而且COPD大鼠肺实质相关的129XeADC直方图也表现出了一定的展宽.这些结果说明了COPD大鼠肺泡空腔的增大能够通过129Xe在肺里面的ADC增长和相关直方图的拓宽反应出来,从而证明了单个b值的扩散加权MRI方法可以有效地对COPD大鼠进行检测.

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