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阿糖胞苷HepDirect前药MB07133的波谱特征与晶体结构

DOI: 10.11938/cjmr20150313, PP. 518-527

Keywords: 核磁共振(NMR),阿糖胞苷HepDirect前药,MB07133,2DNMR,晶体结构,单晶衍射

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Abstract:

用1H和13CNMR和多种2DNMR谱表征了阿糖胞苷的磷酸盐或磷酸酯肝靶向前体药物(HepDirect前药)——MB07133的结构,对其NMR谱进行了归属;用X-射线单晶衍射测定了单晶的晶体结构.讨论了该化合物的波谱数据和晶体结构数据,验证了其结构的正确性并探讨了其化学结构对药物特性的影响.

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