Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT. 2012. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. The Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 67(4): 395-405.
[2]
Boehm M, Slack F. 2005. A developmental timing microRNA and its target regulate life span in C. elegans. Science, 310(5756): 1954-1957.
[3]
Bonauer A, Boon RA, Dimmeler S. 2010. Vascular microRNAs. Current Drug Targets, 11(8): 943-949.
[4]
Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJG, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. 2013. MicroRNA-34a regulates cardiac ageing and function. Nature, 495(7439): 107-110.
[5]
Chim CS, Wong KY, Qi Y, Loong F, Lam WL, Wong LG, Jin DY, Costello JF, Liang R. 2010. Epigenetic inactivation of the miR-34a in hematological malignancies. Carcinogenesis, 31(4): 745-750.
[6]
Cole KA, Attiyeh EF, Mosse YP, Laquaglia MJ, Diskin SJ, Brodeur GM, Maris JM. 2008. A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Molecular Cancer Research, 6(5): 735-742.
[7]
de Lencastre A, Pincus Z, Zhou K, Kato M, Lee SS, Slack FJ. 2010. MicroRNAs both promote and antagonize longevity in C. elegans. Current Biology, 20(24): 2159-2168.
Esquela-Kerscher A, Slack FJ. 2006. Oncomirs - microRNAs with a role in cancer. Nature Reviews Cancer, 6(4): 259-269.
[10]
Friedman DB, Johnson TE. 1988. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics, 118(1): 75-86.
[11]
Garzon R, Calin GA, Croce CM. 2009. MicroRNAs in cancer. Annual Review of Medicine, 60: 167-179.
[12]
Gong J, Tong Y, Zhang HM, Wang K, Hu T, Shan G, Sun J, Guo AY. 2012. Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human Mutation, 33(1): 254-263.
[13]
He YH, Lu X, Wu H, Cai WW, Yang LQ, Xu LY, Sun HP, Kong QP. 2014a. Mitochondrial DNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians. Neurobiology of Aging, 35(7): 1779.e1-1779.e4.
[14]
He YH, Zhang YX, Yang LQ, Liao XP, Zhang QY, Cai WW, Kong QP. 2014b. Assessment of the health status of centenarians in the south of China: a cross-sectional study. Journal of the American Geriatrics Society, 62(7): 1402-1404.
[15]
Herskind AM, McGue M, Holm NV, S？rensen TIA, Harvald B, Vaupel JW. 1996. The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870-1900. Human Genetics, 97(3): 319-323.
[16]
Holstege H, Pfeiffer W, Sie D, Hulsman M, Nicholas TJ, Lee CC, Ross T, Lin J, Miller MA, Ylstra B, Meijers-Heijboer H, Brugman MH, Staal FJT, Holstege G, Reinders MJT, Harkins TT, Levy S, Sistermansl EA. 2014. Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis. Genome Research, 24(5): 733-742.
[17]
Ibá？ez-Ventoso C, Yang MC, Guo SZ, Robins H, Padgett RW, Driscoll M. 2006. Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. Aging Cell, 5(3): 235-246.
[18]
Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Br？nneke HS, Merkwirth C, Kashkar H, Olkkonen VM, B？ttger T, Braun T, Seibler J, Brüning JC. 2011. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nature Cell Biology, 13(4): 434-446.
[19]
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. 1993. A C. elegans mutant that lives twice as long as wild type. Nature, 366(6454): 461-464.
[20]
Li N, Fu HJ, Tie Y, Hu Z, Kong W, Wu YG, Zheng XF. 2009. miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Letters, 275(1): 44-53.
[21]
Liang RQ, Bates DJ, Wang E. 2009. Epigenetic control of microRNA expression and aging. Current Genomics, 10(3): 184-193.
[22]
Lin K, Dorman JB, Rodan A, Kenyon C. 1997. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science, 278(5341): 1319-1322.
[23]
Liu N, Landreh M, Cao KJ, Abe M, Hendriks GJ, Kennerdell JR, Zhu YQ, Wang LS, Bonini NM. 2012. The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature, 482(7386): 519-523.
[24]
Locke JM, Allen HL, Harries LW. 2014. A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetologica, 51(2): 325-329.
[25]
Mcgue M, Vaupel JW, Holm N, Harvald B. 1993. Longevity is moderately heritable in a sample of Danish twins born 1870-1880. Journal of Gerontology, 48(6): B237-B244.
[26]
Noren Hooten N, Abdelmohsen K, Gorospe M, Ejiogu N, Zonderman AB, Evans MK. 2010. microRNA expression patterns reveal differential expression of target genes with age. PLoS One, 5(5): e10724.
[27]
Pincus Z, Smith-Vikos T, Slack FJ. 2011. MicroRNA predictors of longevity in Caenorhabditis elegans. PLoS Genetics, 7(9): e1002306.
[28]
Provost P. 2010. Interpretation and applicability of microRNA data to the context of Alzheimer''s and age-related diseases. Aging, 2(3): 166-169.
[29]
Rokavec M, Li HH, Jiang LC, Hermeking H. 2014. The p53/miR-34 axis in development and disease. Journal of Molecular Cell Biology, 6(3): 214-230.
[30]
Sambrook J, Russell DW. 2006. Purification of nucleic acids by extraction with phenol:chloroform. Cold Spring Harbor Protocols, 2006(1), doi: 10.1101/pdb.prot4455.
[31]
Schraml E, Grillari J. 2012. From cellular senescence to age-associated diseases: the miRNA connection. Longevity & Healthspan, 1(1): 10.
[32]
Sebastiani P, Solovieff N, DeWan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. 2012. Genetic signatures of exceptional longevity in humans. PLoS One, 7(1): e29848.
[33]
Serna E, Gambini J, Borras C, Abdelaziz KM, Belenguer A, Sanchis P, Avellana JA, Rodriguez-Ma？as L, Vi？a J. 2012. Centenarians, but not octogenarians, up-regulate the expression of microRNAs. Scientific Reports, 2: 961.
[34]
Somel M, Guo S, Fu N, Yan Z, Hu HY, Xu Y, Yuan Y, Ning ZB, Hu YH, Menzel C, Hu H, Lachmann M, Zeng R, Chen W, Khaitovich P. 2010. MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Research, 20(9): 1207-1218.
[35]
Terry DF, Wilcox M, McCormick MA, Lawler E, Perls TT. 2003. Cardiovascular advantages among the offspring of centenarians. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 58(5): 425-431.
[36]
Tissenbaum HA, Guarente L. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 410(6825): 227-230.
[37]
Welch C, Chen Y, Stallings RL. 2007. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene, 26(34): 5017-5022.
[38]
Wiggins JF, Ruffino L, Kelnar K, Omotola M, Patrawala L, Brown D, Bader AG. 2010. Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Research, 70(14): 5923-5930.
[39]
Yang J, Chen D, He Y, Meléndez A, Feng Z, Hong Q, Bai X, Li Q, Cai G, Wang J, Chen X. 2013. MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age, 35(1): 11-22.
