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褪黑素对大鼠生长及脂肪代谢、分配的影响

DOI: 10.3969/j.issn.1006-267x.2015.08.018

Keywords: 褪黑素,大鼠,生长,脂肪分配

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Abstract:

本试验旨在研究褪黑素(MT)对动物生长及脂肪代谢、分配的影响。选择日龄、体重接近的SD雄性大鼠50只,随机平均分为5组,每组10只,5组分别为正常饲粮(ND)、正常饲粮+褪黑素(ND+MT)、脂肪添加(FS)、脂肪添加+低剂量褪黑素(FS+LMT)和脂肪添加+高剂量褪黑素(FS+HMT)组。FS组在正常饲粮中添加10%的猪油,ND+MT、FS+LMT、FS+HMT组除饲喂特定饲粮外,分别灌服10、2、20mg/kgBW的MT溶液。试验期60d。结果表明,与ND组相比,ND+MT组日均采食量、平均日增重、肝脏重显著下降(P<0.05);肝脏长链脂肪酸含量、总胆固醇含量、大网膜重、肾周脂肪重、附睾脂肪重均显著降低(P<0.05)。较FS组,FS+LMT组日均采食量、平均日增重、肝脏长链脂肪酸含量、大网膜重、附睾脂肪重降低,肝脏指数显著升高(P<0.05);FS+HMT组的大网膜重、附睾脂肪重较显著降低(P<0.05)。较ND组,FS组肾周脂肪重显著降低(P<0.05),而附睾脂肪重则显著增加(P<0.05)。综上,MT可以降低大鼠的生长速度,减少大鼠肝脏内脂肪的含量,改变脂肪在体内的分配。

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