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OALib Journal期刊
ISSN: 2333-9721
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核转录因子nrf2与肺部炎症疾病研究进展
, PP. 1080-1087
Keywords: 核因子nf-e2相关因子,气道炎症,氧化应激,慢性阻塞性肺疾病,哮喘,急性肺损伤
Abstract:
核因子nf-e2相关因子(nuclearfactorerythroid2-relatedfactor2,nrf2)是氧化应激反应敏感基因的重要转录因子之一,可调节依赖抗氧化反应元件(antioxidantresponseelements,are)的多种抗氧化蛋白的生成。研究显示,nrf2-keap1(kelch样ech联合蛋白1)-are信号通路是细胞内重要的内源性抗氧化防御机制之一,上调该信号通路可诱导其下游调控的多种抗氧化酶及解毒酶,提高谷胱甘肽及超氧化物歧化酶等抗氧化物质的表达水平,清除自由基,维持细胞内氧化还原平衡状态,发挥内源性细胞保护作用。近年来,大气污染尤其pm2.5可能是导致呼吸道炎症发病率升高以及炎症加重的关键因素之一,nrf2及其信号通路对气道炎症性疾病如支气管哮喘、慢性阻塞性肺疾病(chronicobstructivepulmonarydisease,copd)和急性肺损伤(acutelunginjury,ali)的调控,有望成为防治肺部炎症性疾病药物研究潜在性靶点。本文就nrf2与气道炎症和氧化应激相关信号通路调控进行综述。
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